Associate
Research Scientist/Research Scientist/Senior Research
Scientist, Formulation
Pharmaceutical company located in New York seeks an
Associate Research Scientist/Research Scientist/Senior
Research Scientist for the following responsibilities:
oDevelop stable dosage forms including modified release
formulations for new molecular entities.
oInteract with preformulation, exploratory pharmaceutics,
and pharmacokinetics groups for rational formulation
design for Phase I and II studies
oWork in a team based environment within PR & D
and represent Formulation group in project meetings
oEfficiently use all types of processing equipment following
cGMP compliant procedure
oWork independently with minimal supervision.
oWork on multiple projects at different research phases.
Requirements:
oPh.D. with 0-6 years experience in fast track dosage
form development of new molecular entity. Degree in
Pharmaceutical field, Industrial Pharmacy is preferred
(Alternate related fields are acceptable with appropriate
experience).
oMust be knowledgeable of all types of formulations
used in the R &D including novel drug delivery systems
Must have excellent verbal and written communication
skills.
oUnderstanding of FDA requirements including IND, NDA,
Pre Approval Inspections, is desirable.
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Research
Scientist/Senior Research Scientist Preformulation
Pharmaceutical company located in New York is seeking
a Research Scientist / Senior Research Scientist, Preformulation
for the following Responsibilities:
Conduct fundamental physico-chemical characterization
of small drug molecules including pH-solubility profile,
pKa, partition coefficients, polymorphism/salt screening,
solid and solution state stability studies, etc
Conduct drug-excipient compatibility and other relevant
studies to provide active support to formulators in
the formulation development process
Conduct mechanical and thermal property evaluation on
API and formulations using MDSC, TGA, DMA, texture analyzer
and DCA
Perform experiments to monitor physical form change
during pharmaceutical processing
Conduct solubility and multi-media dissolution studies
to support BCS and in vitro/in vivo correlation
Develop oral and IV formulations to support in vivo
PK, TK and pharmacological studies in animals
Supervise chemists and /or Ph.D. scientist to conduct
the above preformulation activities
Requirements:
Ph.D. in Physical Organic Chemistry/Pharmaceutical Chemistry/
Medicinal Chemistry/Analytical Chemistry/Pharmaceutics
with 0-5 years experience in preformulation
Fundamental knowledge of pharmaceutical product development
is a must
Training in analytical techniques and instrumentation
such as HPLC, LC/MS, DSC, TGA, FTIR, Hot-Stage Microscopy,
Vapor Sorption, Isothermal Microcalorimetry, Particle
Size Analysis and XRD is desirable
Expertise/Experience in thermal analytical testing is
a plus
Knowledge of computer data sharing environment and a
good understanding of formulations, especially solid
dosage forms is necessary
Must be able to work in a team environment
Excellent verbal and written communication skills
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